It is impossible to make a memory reader undetectable. All Sony has to do is find the SEQ sniffer code and write the specific code required to detect it. It's trivial to get a list of ring 0 drivers. It's trivial to determine if another process has a handle open to your process.
It is possible to make it exceedingly difficult (basically write a sandbox that intercepts the API calls EQ would make to detect the reader) but Sony has the advantage of SEQ being a purely reactionary response. SEQ cannot be "fixed" until it's determined how Sony "broke" it each time.