I run SEQ on a Quad PPro 200 with no issues that I can tell. SEQ isn't multi-threaded, so the other 3 CPUs spend the vast majority of their time completely idle. I also export the display over my network to a Windows machine running Exceed to actually display SEQ. I keep the map refresh rate down around 2fps since I don't need it to update very fast in the large outdoor zones that I hunt in.

Maybe by this weekend I'll get into an adventure with a couple of friends and record the session just to capture the data.